题 目：Lung on fire by bacterial infection, can non-coding RNA contain it
时 间：2018.11.16（星期五）上午10:30
地 点：图书馆402播放厅
报告人：北达科他大学 吴敏教授
成都医学院科技处
成都医学院检验医学院
2018.11.15
附：吴敏教授简介
Min Wu, M.D., Ph.D. is a Professor at School of Medicine, University of North Dakota, USA. He obtained his PhD from Leeds Univ., UK. In order to understand the mechanisms of and discover better cures for infectious diseases, Min is interested in fundamental pathogenesis of P. aeruginosa respiratory infection and host-pathogen interaction, involving host autophagy process, non-coding RNA regulation, and bacterial CRISPR-Cas immunity. He is an internationally recognized scientist in both lung biology (asthma and lung injury repair) and Pseudomonas infection. He has been funded by NIH (currently funded with 2R01s) and other agencies for the last 20 years and collaborates with outstanding scientists worldwide. He has published more than 138 papers in high-quality journals (Nat Commun, Nat Microbiol, Cell Host Microbe, Sci Signal, Cell Res, PNAS USA, PLOS Pathog, Autophagy, Gastroenterology, Am J Respir Crit Care Med, etc.). Dr. Wu has served committee chair positions in professional societies and meeting chair or session chair of international conferences. He serves as associate editor for J Immunol, Nanomedicine, Sci Reports, PLoS One, etc. Dr. Wu has been invited to speak in major conferences (Gordon, AAI, SLB, ASBMB, etc.) and at renowned institutions (Yale, UAB, etc.) in the world and is a regular reviewer for NIH grants and high quality journals (Nat Commun, Nat Microbiol, PNAS, etc.). Dr. Wu has trained more than thirty graduate students and postdocs, some mentees became a leader in the field. He has won many awards including the UND Collaborative Research Award and Overseas Research Scholarship in UK.
重要论文：
1. Zhou X, Li X, Ye Y, Li Y, Privratsky B, Wang W, Wei Y, andWu M. MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to the TLR/IRAK4 circuit.Nat Commun2014;5, Article number: 3619, doi:10.1038/ncomms4619.（Selected by F1000Prime - special significance in its field by F1000 Faculty.）（IF:12.4）
2. Li R, Fang L, Yu M, Li X, Pu Q, Weiland T, Bansal A, Ye SQ, Jiang J andWu M.Long noncoding RNA MEG3-4 is a tissue specific regulator of IL-1b in pulmonary infection by repressing micoRNA-138.Sci SignalJun 26 2018;11(536). pii: eaao2387. doi: 10.1126/scisignal.aao2387. (IF: 6.378)
3. Pu Q, Gan C, Li R, Li Y, Tan S, Li X, Wei Y, Ma F, andWu M. Atg7 deficiency intensifies inflammasome activation and pyroptosis inPseudomonassepsis.J Immunol2017; 198(8):3205-3213. doi: 10.4049/jimmunol.1601196. (IF: 4.538)
4. Ye Y, Lin P, Zhang W, Tan S, Zhou X, Li R, Pu Q, Koff JL, Dhasarathy A, Ma F, Deng X, Jiang J, andWu M.DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia.J Immunol.2017;198(7):2844-2853. doi: 10.4049/jimmunol.1601001. (IF: 4.538)
5. Wang X, Yang X,LiY, Wang X, Zhang Y, Dai X, Niu B, Wu J, Yuan X, Xiong A, Liu Z, Zhong N,Wu M,and Li G. Lyn kinase repressesmucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma.EBioMedicine 2016 Dec 21. pii: S2352-3964(16)30589-8. doi: 10.1016/j.ebiom. (IF: 6.138)
6. Li R, Fang L, Pu Q, Lin P, Kannan S, Hoggarth A, Huang H, Li X, Li G, andWu M. Lyn negatively regulatesPseudomonas aeruginosa-induced inflammatory responsesthrough IL-6/STAT3/SHIP-1 signaling axis.Signaling Transduct Target Ther.2016;1, Article number: 16032 (2016) doi:10.1038/sigtrans.2016.32
7. Li R, Tan S, Yu M, Li X, He S, Wei Y, Jiang JX, andWu M.Pseudomonas aeruginosaevades host immunity by Type I CRISPR-Cas mediated endogenous targeting.CellResearch2016;26(12):1273-1287. doi: 10.1038/cr.2016.135. (with accompany research highlight paper and cover image) (IF: 15.353)
8. Li X, He S, Zhou X, Li R, Zhang S, Yu M, Ye Y, Wang Y, Li G, Huang C, andWu M.Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-mediated immune activation and infiltration.Nature Microbiology2016;1, Article number: 16132 (2016), doi:10.1038/nmicrobiol.2016.132. (IF: 14.174)
9. He S, Li X, Li R, Wang K, Fang L, Wang Y, andWu M. Annexin A2 modulates ROS and thus impacts inflammatory response via IL-17 signaling in polymicrobial sepsis mice.PLoS Pathogens2016; Jul 7;12(7):e1005743. doi: 10.1371/journal.ppat.1005743. (IF:7.7)
10. Li X, He S, Ye Y, Zhou X, Tan S, Jundt M.C., Lenz C, Lichter N, Hidebrand A, Wang Y, Li G, Huang C, andWu M. Lyn delivers bacterial substance to lysosomes for eradication through TLR-2-initiated and autophagy-mediated phagocytosis.PLoS Pathogens2016 Jan 6;12(1):e1005363. doi: 10.1371/journal.ppat.1005363. (IF:7.7)
11. Yuan K, Lei Y. Chen H, Chen Y, Zhang T, Li K, Xie N, Wang K, Feng X, Pu Q, Yang W,Wu M,Xiang R, Nice EC, Wei Y, and Huang C. HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3.Cell Death Diff 2016; 23(4):616-27. doi: 10.1038/cdd.2015.129. (IF:8)
12. Ye Y, Tan S, Zhou X, Li X, Jundt MC,Lenz C, Lichter N,Hidebrand A,andWu M. Atg7 inhibits ubiquitylation of p-IkBa to regulate the inflammatory responses in host defense against bacterial infection.J Infect Dis2015;212(11):1816-26. (IF:5.186)
13. Liang H, Deng X, Ye Y, Li X, andWu M.Molecular Mechanisms of Master Regulator VqsM mediating Quorum-sensing and Antibiotic Resistance in Pseudomonas aeruginosa. Nucleic Acids Res 2014;42(16):10307-20 (IF:11.561)
14. Yuan K, Xie K, Fox J III, Zeng H, Gao H, Huang C, andWu M. Decreased Levels of miR-224 and the Passenger Strand of miR-221 Increase MBD2, Suppressing Maspin and Promoting Colorectal Tumor Growth and Metastasis in Mice.Gastroenterology 2013; 145(4):853-864. (IF:20.7)
15. M Wu,S Hussain, YH He, R Pasula, P Smith and WJ Martin II. Genetically Engineered Macrophages Expressing IFN-g Restore Alveolar Immune Function in scid Mice.Proc Nat Acad Sci USA2001; 98:14589-14594. (*Highlighted by Nature Rev Immunol 1, 2002, commentary paper inIndianapolis Starand cited by NIH website bite) (IF: 9.504)
