题 目：Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice
时 间：2018.10.16（星期二）10:00
地 点：新都校区多功能厅
报告人：唐建荣教授
附：唐建荣教授简介
唐建荣教授现任美国贝勒医学院得克萨斯州儿童医院邓肯神经病学研究所“神经生理学中心实验室”主任、美国国立卫生研究所智力与发育研究中心所属贝勒医学院 “神经联系中心实验室”主任。唐建荣实验室主要研究神经发育性神经疾病（如Rett syndrome, Angelman syndrome等）认知障碍、运动功能异常等方面的神经机制及功能恢复。新近在Rett Syndrome的小鼠模型上发现，定位深部脑刺激通过调节大脑海马结构的神经再生和突触可塑性，可恢复模式动物的学习与记忆功能。在转基因动物的行为学、电生理学及药理学分析方面具有开创性的技术和经验，所涉领域包括认知神经科学、行为生物学、神经病学等。近5年，实验室在《Nature》、《Neuron》、《Journal of Neuroscience》、eLIFE等学术刊物上发表论文30余篇。论文被美国神经科学学会评选为2017年最重要的3篇论文之一。
重要论文：
1. Shuang Hao, Bin Tang, Zhenyu Wu, Kerstin Ure, Yaling Sun, Huifang Tao, Yan Gao, Akash J. Patel, Daniel J. Curry, Rodney C. Samaco, Huda Y. Zoghbi andJianrong Tang. 2015. Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice.Nature, 526: 430-434.(Highlighted in News and View:Nature, 526: 331-332; Nature Review Neurology, 11: 666, 2015; Faculty 1000, and internet press releases). (影响因子：41.46)
2. Yehezkel Sztainberg, Hongmei Chen, John W. Swann, Shuang Hao, Bin Tang, Zhenyu Wu,Jianrong Tang, Ying-Wooi Wan, Zhandong Liu, Frank Rigo and Huda Y. Zoghbi. 2015. Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligos.Nature, 528: 123-126.(影响因子：41.46)
3. Jianrong Tangand John A. Dani. 2009. Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. Neuron, 63: 673-682 (Highlighted in Neuron, 63: 564-565; Faculty 1000; internet press releases). (影响因子：15.05)
4. Kihoon Han, J. Lloyd Holder, Jr Christian P. Schaaf, Hui Lu, Hongmei Chen, Hyojin Kang,Jianrong Tang, ZhenyuWu, Shuang Hao, SauWai Cheung, Peng Yu, Hao Sun, Amy M. Breman, Ankita Patel, Hui-Chen Lu & Huda Y. Zoghbi. 2013.SHANK3overexpression causes manic-like behaviour with unique pharmacogenetic properties.Nature, 503: 72-77.(影响因子：41.46)
5. Giovanni Marsicano, Carsten T. Wotjak, Shahnaz C. Azad, Tiziana Bisogno, Gerhard Rammes, Maria Grazia Cascio, Heike Hermann,Jianrong Tang, Clementine Hofmann, Walter Zieglgänsberger, Vincenzo Di Marzo and Beat Lutz. 2002. The endogenous cannabinoid system controls extinction of aversive memories.Nature,418: 530-534. (影响因子：41.46)
6. Feng Wei, Xiaoming Xia,Jianrong Tang, Shalle Ko, Jason Liauw, Changshen Qiu and Min Zhuo. 2003. Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioural response: a microelectroporation study in adult rodents.J. Neurosci.,23: 8402-8409. (IF = 6.34)
7. Long-Jun Wu, Hiroki Toyoda, Ming-Gao Zhao, Yong-Seok Lee,Jianrong Tang, Shanelle W. Ko, YongHeng Jia, Celina V. Zerbinatti, Guojun Bu , Feng Wei, Tian-Le Xu, Louis J. Muglia, Zhou-Feng Chen, Yves P. Auberson, Bong-Kiun Kaang and Min Zhuo. 2005. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.J. Neurosci.,25: 11107-11116. (影响因子：6.34)
8. Kornelia Kamprath, Giovanni Marsicano,Jianrong Tang, Krisztina Monory, Tiziana Bisogno, Vincenzo Di Marzo,Beat Lutz, and Carsten T. Wotjak. 2006. Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes.J. Neurosci.,26: 6677-6686. (影响因子：6.34)
9. Tao Zhang#,Jianrong Tang#, Volodymyr I. Pidoplichko and John A. Dani. 2010. Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation.J. Neurosci., 30: 6443-6453.(#: equal contribution) (影响因子：6.34)
10. Daniel Jenson, Kechun Yang, Alexandra Acevedo-Rodriguez, Amber Levine, John I. Broussard,Jianrong Tang, John A. Dani. 2014. Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity.Neuropharmacology, 90: 23-32.(影响因子：5.11)
11. Xiangling Meng, Wei Wang, Hui Lu, Ling-jie He, Wu Chen, Marta L. Fiorotto, Bin Tang, Eugene Chao, Jose A. Herrera, Michelle L. Seymour, Jeffrey L. Neul, Fred A. Pereira,Jianrong Tang, Mingshan Xue, and Huda Y. Zoghbi. 2016. Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders.eLIFE(accepted)(影响因子：9.32)
12. Kerstin Ure, Hui Lu, Wei Wang, Aya Ito-Ishida, Zhenyu Wu, Ling-jie He, Yehezkel Sztainberg, Wu Chen,Jianrong Tang, and Huda Y. Zoghbi. 2016. Restoration ofMecp2expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett Syndrome.eLIFE(accepted)(影响因子：9.32)
